Indications
Type 2 diabetes mellitus, especially in overweight patients with ineffective diet therapy and exercise.
Can be used as monotherapy or in combination with other oral hypoglycemic drugs and insulin

Use during pregnancy and breastfeeding
The drug is contraindicated for use during pregnancy and lactation (breastfeeding).
The patient should be warned about the need to notify the doctor if pregnancy occurs. When planning or becoming pregnant in a patient with type 2 diabetes mellitus, the drug should be discontinued and blood glucose levels should be normalized or brought as close to normal as possible using insulin therapy to reduce the risk of developing defects in the fetus due to the pathological effects of hyperglycemia.
Metformin passes into the milk of laboratory animals. There are no similar data for humans, so a decision should be made to stop breastfeeding or to discontinue the drug Siofor®, taking into account the need to use the drug in the mother.

Contraindications
     Hypersensitivity to metformin or other components of the drug;
     diabetic ketoacidosis, diabetic precoma;
     renal failure or impaired renal function (creatinine clearance <60 ml/min);
     acute conditions that can have a negative impact on kidney function (for example, dehydration, severe infectious disease);
     intravascular injection of iodinated contrast agent;
     acute or chronic diseases that can cause tissue hypoxia (for example, cardiac or respiratory failure, recent myocardial infarction, shock);
     liver failure;
     lactic acidosis (including history);
     pregnancy and lactation (breastfeeding);
     acute alcohol intoxication, chronic alcoholism;
     following a low-calorie diet (less than 1000 kcal/day);
     children under 10 years of age.

Carefully:
  the drug should be used in children aged 10 to 12 years; in patients over 60 years of age who perform heavy physical work, which is associated with an increased risk of developing lactic acidosis.

Storage conditions
In a place protected from light, at room temperature.

Best before date
3 years